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原发性巨球蛋白血症(Waldenstr(?)m’s macro-globulinemia,简称 WM)是一种少见的免疫增殖性疾病,系 B 淋巴细胞恶性增殖,产生大量单株巨球蛋白—M 蛋白,而引起的一系列临床及血液学异常。临床有乏力、贫血、出血、肝脾及淋巴结肿大、视网膜病变、血沉增快、异常高球蛋白血症及高粘稠度血症等。本病于1944年由 Waldenstr(?)m 首先发现而命名.近年国内曾有2例报道.我院于1980年3月收治1例.现报道如下:许××,男,63岁,工人,江苏籍,住院号145143,1980年8月14日入院。患者自1979年8月起渐感乏力进行性加重伴两下肢瘀点和球结膜出血。饮食如常,无发热、盗汗、体重减轻及肢端青紫.1962年起有慢性荨麻疹、关节痛,服强的松10～15毫克/日、安乃近1.0/日,已17年。1977年因高热、症状
The primary macroglobulinemia (WM) is a rare immunoproliferative disorder characterized by malignant proliferation of B lymphocytes and the production of large numbers of monoclonal macroglobulin-M proteins Cause a series of clinical and hematological abnormalities. Clinical fatigue, anemia, bleeding, liver and spleen and lymph nodes, retinopathy, ESR, abnormal hypergammaglobulinemia and hyperviscosity sepsis. The disease was first discovered and named by Waldenstr (?) M in 1944. There were 2 cases reported in China in recent years and 1 case was treated in our hospital in March 1980. It is reported as follows: Xu XX, male, 63 years old, worker, Jiangsu membership, hospital number 145143, August 14, 1980 admission. Since August 1979, the patient became less and less fatigued with two lower extremity petechiasis and bulbar conjunctival hemorrhage. Normal diet, no fever, night sweats, weight loss and bruising .1962 chronic urticaria, arthralgia, prednisone 10 ~ 15 mg / day, metamizole 1.0 / day, 17 years. 1977 due to fever, symptoms