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目的 了解严重急性呼吸综合征 (SARS)患者康复后短期内血清中冠状病毒特异性抗体IgG的产生水平及其动态变化 ,为该病的下一步预防、监测及疫苗的保护效力等提供线索。方法 自 2 0 0 3年 5～ 12月 ,每隔 2～ 4周抽取IgG抗体阳性的SARS康复者的血液 ,经病毒灭活后分离血清 ,用酶联免疫吸附法对SARS病毒特异性抗体IgG进行检测。结果用Stata 7 0软件进行分析。结果 康复期SARS患者以出院后约 35d时抗体平均水平最高。 8个月内 ,IgG抗体平均水平呈逐渐下降趋势 ,降幅约为 2 7 3% (8个月间的抗体水平经统计学检验差异有显著意义 :F =5 76 5 2 ,P =0 0 0 4 6 )。结论 全部SARS康复者皆产生了冠状病毒特异的IgG类抗体 ,但随着康复时间的推移 ,该抗体呈逐渐下降趋势。应对该抗体进行长期的监测
Objective To understand the level of serum coronavirus specific IgG and its dynamic changes in patients with severe acute respiratory syndrome (SARS) shortly after rehabilitation so as to provide clues for the prevention and monitoring of the disease and the protective efficacy of the vaccine. Methods Blood samples of SARS-positive SARS-positive patients were collected every 2 ~ 4 weeks from May 2003 to December 2003. After inactivated by virus, the serum was separated and the anti-SARS virus-specific IgG Test. The results were analyzed using Stata 7 software. Results In the convalescent SARS patients, the average level of antibody was the highest at about 35 days after discharge. Within 8 months, the average level of IgG antibody showed a gradual downward trend, with a decrease of about 27.3% (8-month antibody level was statistically significant difference: F = 5 76 5 2, P = 0 0 0 4 6). Conclusions All SARS patients developed coronavirus specific IgG antibodies, but the antibody showed a gradual decrease with the recovery time. The antibody should be monitored over the long term