论文部分内容阅读
二至丸由女贞子和墨旱莲两味中药组成，这两味药及其组方均有不同程度的保肝作用。二至丸中含有多种保肝有效成分，主要有三萜类、环烯醚萜类、苯乙醇-苷类、香豆素醚类等，它们能对抗多种化学性肝损伤、抗缺血再灌注性肝损伤以及抗肝纤维化等，其保肝作用机制包括抗氧化应激、抗炎、抑制肝星状细胞增殖和活化、促进肝星状细胞凋亡以及影响肝细胞代谢过程等。总结二至丸及其组成药味女贞子和墨旱莲的保肝作用，探讨其保肝作用机制，以期为进一步研究二至丸药效物质基础提供参考。“,”Erzhiwan includes two components of Chinese herbal medicines - Ligustri Lucidi Fructus and Herba Eclip-tae .Ligustri Lucidi Fructus ,Herba Ecliptae and their formulation have various hepatoprotective effects .There are many ac-tive ingredients in the formulation ,such as triterpenes ,iridoids ,phenethyl alcohol-glucosides ,coumarin ethers ,etc .They can resist various chemistry-induced hepatic injury ,ischemia reperfusion induced hepatic injury ,and hepatic fibrosis .The mecha-nisms of hepatoprotective effect include anti-oxidative stress ,anti-inflammatory ,inhibition of hyperplasia and activation of liver stellate cell ,motivating the apoptosis of liver stellate cell ,influencing the metabolic processes of liver cell ,ect .We reviewed and summarized the hepatoprotective effects of Erzhiwan and its components Ligustri Lucidi Fructus and Herba Ecliptae and explore the mechanisms of hepatoprotective effect in order to provide information for further research of pharmacodynamic ma-terial base .