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据美国报道，由于核因子（ＮＦ）－κＢ与恶病质肌肉萎缩进程相关，故抑制ＨＦ－κＢ可能会有益于恶病质的治疗。 通过对鼠肌细胞的骨骼肌分化过程分析，发现肿瘤坏死因子（ＴＮＦ）是一种ＮＦ－κＢ激动剂，它可以阻断肌细胞的骨骼肌分化程序，还能降低为失活肌肉补充养份的Ｍ
It has been reported in the United States that inhibition of HF-κB may be beneficial in the treatment of cachexia due to the association of nuclear factor (NF) -κB with cachexia muscle atrophy. Through the analysis of the skeletal muscle differentiation of rat muscle cells, it is found that tumor necrosis factor (TNF) is an NF-κB agonist which can block muscle cell differentiation process of skeletal muscle and can also reduce the supply of nutrients to inactivated muscle M