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目的以 99m Tc-甲氧基异丁异腈 ( MIBI)心肌断层显像定量分析法 ,评估苯那普利对慢性肾功能衰竭患者心肌血流灌注和存活心肌的影响。方法 2 9例慢性肾功能衰竭患者口服 10～ 2 0 mg/d苯那普利 4周 ,观察治疗前后心肌摄取率的变化。结果 2 0 %～ 3 9%的节段治疗后摄取率无明显增加 ( P>0 .0 5 ) ;40 %～ 5 9%和≥ 60 %节段治疗后摄取率明显增加 ( P均 <0 .0 5 )。结论苯那普利对慢性肾功能衰竭患者心肌血流灌注和存活心肌有显著影响 ,可增加心肌血流量 ,改善存活心肌的功能。
Objective To evaluate the effect of benazepril on myocardial perfusion and myocardial viability in patients with chronic renal failure by 99m Tc-MIBI myocardial perfusion quantitative analysis. Methods Twenty-nine patients with chronic renal failure were treated with benazepril 10 ~ 20 mg / d for 4 weeks, and the change of myocardial uptake was observed before and after treatment. Results There was no significant increase in the uptake rate between 20% and 39% of the segments (P> 0.05). The uptake rates of 40% ~ 59% and ≥ 60% .0 5). Conclusion Benazepril has significant effects on myocardial perfusion and viable myocardium in patients with chronic renal failure, which can increase myocardial blood flow and improve myocardial viability.