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观察中药复方肠露灌肠剂对乙酸诱发小鼠溃疡性结肠炎(UC)模型的治疗作用。将实验小鼠随机分为正常组、模型组、肠露组、柳氮磺吡啶(SASP)组4组,给药治疗7d后,比较各组小鼠的疾病活动指数(DAI),结肠炎症反应及结肠组织病理学变化。结果:肠露对小鼠UC能明显减少疾病活动指数,与模型组比较有非常显著性差异(P<0.01);并能明显减轻结肠炎症反应,与模型组比较差异有显著性(P<0.05);病理检查示模型组小鼠结肠粘膜糜烂、溃疡形成、炎细胞浸润明显,肠壁增厚;肠露组小鼠结肠粘膜未见糜烂及溃疡形成,炎细胞浸润轻,粘膜轻度充血。结论:中药复方肠露灌肠剂对小鼠UC有明显的疗效。
Observe the therapeutic effect of Chinese compound compound bowel enema agent on acetic acid-induced ulcerative colitis (UC) model in mice. The experimental mice were randomly divided into four groups: normal group, model group, intestinal dew group, and sulfasalazine (SASP) group. After 7 days of treatment, the disease activity index (DAI) and the colonic inflammatory response of the mice were compared. And histopathological changes in the colon. RESULTS: Intestinal dew could significantly reduce the disease activity index in mice with UC compared with the model group (P<0.01), and it could significantly reduce the colonic inflammatory response, which was significantly different from the model group (P<0.05). Pathological examination showed that mice in the model group had erosion of the colon mucosa, ulcer formation, infiltration of inflammatory cells, and thickening of the intestinal wall. There was no erosion and ulceration in the colon mucosa of the mice in the intestinal dew-exposed group. The infiltration of inflammatory cells was mild and the mucosa was lightly congested. Conclusion: The Chinese compound compound bowel enema has obvious curative effect on mouse UC.