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目的:探讨抗柯萨奇B病毒性心肌炎胶囊(K-CoxB-JN)复方总多糖(polysaccharide)对阿霉素(ADM)致心肌损伤小鼠心肌酶的影响。方法:注射ADM建立小鼠心肌损伤模型,随机平均分为7组,正常组,模型组,多糖高、中、低剂量组(给药剂量分别为4.4g/kg,2.2g/kg,1.1g/kg),原方水煎组(6g/kg)和心血康组(0.1g/kg),分别灌胃给予相应的药物,每天1次。给药第8天造模,24h后摘除眼球取血处死全部小鼠检测AST、ALT、CK、LDH、HBDH。结果:模型组五项心肌酶指标明显高于正常组(P<0.01)。与模型组比较各药物治疗组五项心肌酶有不同程度的降低,其中多糖高剂量组心肌酶明显降低(P<0.01)。结论:多糖对心肌损伤小鼠心肌酶的有抑制作用,呈现明显的量效关系。
Objective: To investigate the effect of K-CoxB-JN compound polysaccharide on cardiac enzymes in adriamycin-induced myocardium injury in mice. Methods: The model of myocardial injury in mice was established by injecting ADM. The models were randomly divided into 7 groups: normal group, model group, high, medium and low dose polysaccharide groups (the dosage was 4.4g / kg, 2.2g / kg, 1.1g / kg), the original decoction group (6g / kg) and Xuexuekang group (0.1g / kg) were given the corresponding drug by gavage once a day. On the 8th day after administration, the mice were sacrificed after removal of the eyeballs for 24 hours. AST, ALT, CK, LDH and HBDH were detected in all the mice. Results: The indexes of myocardial enzymes in model group were significantly higher than those in normal group (P <0.01). Compared with the model group, the five myocardial enzymes in each drug treatment group decreased to some extent, and the myocardial enzymes in high-dose polysaccharide group were significantly decreased (P <0.01). Conclusion: Polysaccharides can inhibit myocardial enzymes in mice with myocardial injury, showing a significant dose-response relationship.