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自身免疫性肝炎(autoimmune hepatitis,AIH)是特异性自身抗原表达或细胞、细胞浆等非特异性自身抗原表达引起自身肝组织损伤的特殊类型的慢性肝炎,血清学显示高丙种球蛋白和自身抗体。AIH是一多器官受累的疾病,发病率世界各地不同,在北美和西欧的白种人AIH发病是慢性肝炎的20％,我国是慢性肝炎住院患者的0.56％。AIH通常分3型。无论男、女、老少均有发病,发病平均年龄女性(35±52)岁,男性(44±83)岁,男女之比1∶5。1999年国际自身免疫性肝炎小组(IAIHG)公布新的国际临床诊断评分标准,已引起国内对AIH的重视,我国对AIH报道也逐渐增多,但是对AIH的全面了解尚有差距。
Autoimmune hepatitis (AIH) is a special type of chronic hepatitis with specific autoantigen expression or non-specific autoantigen such as cell and cytoplasm expresses own liver tissue damage. Serum shows high gammaglobulin and autoantibodies. AIH is a multiorgan-affected disease with a worldwide prevalence. White AIH incidence is 20% of chronic hepatitis in North America and Western Europe, and 0.56% of patients with chronic hepatitis in our country. AIH usually divided into 3 types. The average age of onset was 35 ± 52 years in men and 44 ± 83 years in men with a ratio of men to women of 1: 5. The International Autoimmune Hepatitis Group (IAIHG) released a new International clinical diagnostic scoring standards have caused domestic attention to AIH, our country reports on AIH also gradually increased, but a full understanding of AIH is still a gap.