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应用补体介导细胞毒法体外消除２例白血病骨髓中残存瘤细胞，并作自身骨髓移植。用国产ＣＤ７单抗（ＬＮ６７－８及ＬＳ９３－２，ＩｇＧ２ｂ）首次净化１例Ｔ－ＡＬＬ骨髓及ＣＤ１０单抗（５５，ＩｇＧ２ａ）净化１例ＣＡＬＬＡ＋－ＡＬＬ。靶细胞清除率均达３个对数级，骨髓ＣＦＵ－ＧＭ回收率分别为５７．６％～７５．８％及５１．７％～７２．３％。Ｔ－ＡＬＬ病人移植后２６天获造血重建。现已完全缓解３年，首次证实国产单抗ＬＮ６７－８及ＬＳ９３－２净化骨髓有效、安全。
Application of complement-mediated cytotoxicity in vitro to eliminate residual leukemia in 2 cases of bone marrow cells, and for their own bone marrow transplantation. One case of CALLA + -ALL was purified by CD69 monoclonal antibody (LN67-8, LS93-2, IgG2b) and T-ALL bone marrow and CD10 monoclonal antibody (55, IgG2a). The target cell clearance rate reached 3 logarithmic levels, and the bone marrow CFU-GM recoveries were 57.6% -75.8% and 51.7% -72.3%, respectively. T-ALL patients were hematopoietic reconstructed 26 days after transplantation. Has been completely relieved for 3 years, for the first time confirmed that the domestic monoclonal antibody LN67-8 and LS93-2 purification of bone marrow effective and safe.