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内皮素(Endothelin)是血管内皮细胞分泌的强效缩血管活性多肽。我们曾证实,内皮素的过量释放,是一些心血管病急、危、重症的重要发病因素之一(生理学报1989;41:489,中国循环杂志1990;5:194)。但迄今尚无特异性内皮素的拮抗剂或受体阻断剂,为此我们制备了兔抗大鼠内皮素的抗体,建立了内皮素放射免疫测定方法,以观察内皮素抗血清对实验性心血管疾病发病过程的影响。 1.肾性高血压;大鼠部分结扎腹主动脉和高盐摄入,4周后血压从13.1±0.6升至27.3±0.9kPa血浆内皮素浓度从4.1±0.3增至9.7±0.7Pg/ml
Endothelin is a potent vasoactive polypeptide secreted by vascular endothelial cells. We have confirmed that excessive release of endothelin is one of the most important risk factors for acute, critical, and severe cardiovascular diseases (Acta Physiologica Sinica 1989; 41:489, China Circulation Journal 1990; 5:194). However, there are no specific endothelin antagonists or receptor blockers. To this end, we have prepared rabbit anti-rat endothelin antibodies and established an endothelin radioimmunoassay method to observe that endothelin antiserum is experimentally The impact of the pathogenesis of cardiovascular disease. 1. Renal hypertension; Partial rat ligation of abdominal aorta and high salt intake, 4 weeks after the blood pressure rose from 13.1 ± 0.6 to 27.3 ± 0.9kPa plasma endothelin concentration increased from 4.1 ± 0.3 to 9.7 ± 0.7Pg/ml