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目的调查并确定某院内分泌科糖尿病住院患者2012年3月~2013年2月药疗医嘱中潜在药物间相互作用(DDIs)及涉及的药物类别,为医师及临床用药管理提供依据。方法收集某院1年中内分泌科糖尿病住院患者的药疗医嘱,结合医院药物信息支持系统及临床药师手工筛查检测处方药物潜在药物相互作用。结果 1年内在某三甲医院内分泌科住院的糖尿病患者共450人。入院前1个月内或住院期间检查的糖化血红蛋白平均值为(9.4±2.4)%,平均病程为(11.0±8.1)年。住院患者中使用最多的治疗方案为胰岛素治疗,其次为胰岛素与α糖苷酶抑制剂联合使用方案。发生DDIs较多的药物为阿司匹林及β受体阻滞剂。结论由于内分泌科住院患者中存在多种常用药物之间的DDIs,会给患者带来潜在的医疗风险,有必要研发结合本院实际情况快速自动预警系统用以防止发生DDIs。临床医师必须对潜在的DDIs有所了解,同时临床药师需要及时审查医嘱,保证药物治疗的质量与安全。
Objective To investigate and determine the potential drug-drug interactions (DDIs) and the types of drugs involved in the hospitalization of patients with diabetic end-stage diabetes mellitus in a hospital from March 2012 to February 2013, and provide the basis for physicians and clinical medication management. Methods The medical prescriptions of hospitalized patients with endocrine diabetes mellitus in one hospital for one year were collected, and the potential drug interactions of prescription drugs were detected by manual screening with hospital drug information support system and clinical pharmacists. Results A total of 450 diabetic patients hospitalized in the endocrinology department of a top three hospital within one year. The average value of HbA1c within 1 month before admission or hospitalization was (9.4 ± 2.4)% and the average course of disease was (11.0 ± 8.1) years. The most commonly used treatment regimen for hospitalized patients is insulin therapy, followed by a combination of insulin and alpha-glucosidase inhibitors. DDIs occurred more drugs for aspirin and beta blockers. Conclusion Due to the presence of DDIs among various commonly used drugs in hospitalized endocrinology patients, it poses a potential medical risk to patients. It is necessary to develop a rapid automatic warning system based on the actual conditions in our hospital to prevent the occurrence of DDIs. Clinicians must understand potential DDIs, and clinical pharmacists need to review their orders promptly to ensure the quality and safety of drug treatment.