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临床上口服药物的常规给药时间多安排在白天,每日两次为8-4(或8-6),每日三次为8-12-4(或8-12-6)。此种给药时间对要求血药浓度恒定的药物,常可影响疗效。因此,为了维持有效的血药浓度,需按一定间隔时间给药。我科对一例应用丙戊酸钠治疗的癫痫患者,根据血药浓度对服药时间进行调整,收效较好。现报道如下。病例介绍患者男,11岁。因外伤后发作性四肢抽搐三年,诊断外伤性癫痫入院。给予苯妥因钠0.1每日三次,疗效不佳。后改用丙戊酸钠治疗,服药后同时监测血药浓度。开始给予丙戊酸钠0.2口服,每日二次,患者间隔2～3日仍有四肢小抽搐,测血药浓度为20μg/
Clinically oral administration of conventional drug time and more arranged in the daytime, twice daily for 8-4 (or 8-6), three times a day for the 8-12-4 (or 8-12-6). This kind of drug delivery time requires a constant concentration of blood drug, often can affect the curative effect. Therefore, in order to maintain an effective plasma concentration, medication should be administered at regular intervals. Our department for a case of epilepsy patients treated with sodium valproate, according to the concentration of blood on the medication time adjustment, better effect. Report as follows now. Case description Patient male, 11 years old. After traumatic episodes of limbs twitching for three years, diagnosis of traumatic epilepsy admission. Give phenytoin sodium 0.1 three times a day, poor efficacy. After the switch to sodium valproate treatment, after taking the drug at the same time monitoring blood concentration. Began to give sodium valproate 0.2 oral, twice daily, patients still 2-3 days interval jaundice, measured blood concentration of 20μg /