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To evaluate results of photodynamic therapy (PDT) with verteporfin for subfove al neovascular age-related macular degeneration (ARMD) with retinal angiomatous proliferation (RAP) and pigment epithelial detachment (PED). Interventional cas e series. Thirteen eyes (11 stage 2 and 2 stage 3 RAP) underwent PDT. Best-corr ected visual acuity (BCVA), fluorescein and indocyanine-green angiography were performed to evalu ate the outcome. After 13.5 ±2.5 months and 1.7 ±0.4 treatments, mean BCVA dec reased from 20/73 to 20/174 (P=. 04). Occlusion of RAP and flattening of PED was observed in three eyes, and persistence of PED in six. Two eyes deteriorated to disciform lesions, one developed hemorrhagic PED, and one evolved toward stage 3 RAP. Three eyes, with PED exceeding 50%of the entire lesion, developed retina l pigment epithelium tear. PDT might prove effective for neovascular ARMD with R AP and small PED, whereas it might cause acute retinal pigment epithelium tear f or RAP with PED exceeding 50%of the lesion.
To evaluate the results of photodynamic therapy (PDT) with verteporfin for subfoveal neovascular age-related macular degeneration (ARMD) with retinal angiomatous proliferation (RAP) and pigment epithelial detachment (PED). Interventional cas series. Thirteen eyes (11 stage 2 and 2 stage 3 RAP) underwent PDT. Best-corr ected visual acuity (BCVA), fluorescein and indocyanine-green angiography were performed to evaluate ate the outcome. After 13.5 ± 2.5 months and 1.7 ± 0.4 treatments, mean BCVA decased from 20 / 73 to 20/174 (P = .04). Occlusion of RAP and flattening of PED was observed in three eyes, and persistence of PED in six. Two eyes deteriorated to disciform lesions, one developed hemorrhagic PED, and one evolved toward stage 3 RAP. Three eyes, with PED exceeding 50% of the entire lesion, developed retina l pigment epithelium tear. PDT might prove effective for neovascular ARMD with R AP and small PED, yet it might cause acute retinal pigment epithelium tear f or RAP with PED exce eding 50% of the lesion.