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目的:探讨男性OSAHS患者神经认知功能与睡眠结构的相关性。方法:采取病例对照研究,66名OSAHS患者和38名年龄、性别、文化程度相匹配的正常对照组分别完成蒙特利尔量表(MoCA)、韦氏成人记忆测验(WMS)、威斯康辛卡片分类测验(WCST)、Stroop色词测验(SCWT)及Epworth嗜睡量表(EES)的评估,并完成整夜多导睡眠描记检查(PSG)。结果:OSAHS组MoCA、WMS、WCST、SCWT各项分值与对照组的差异均具有显著性(Ps<0.05或0.001)。OSAHS组EES分值高于对照组,睡眠效率、NREM 2期和REM期百分比明显低于对照组,进入REM睡眠时间也明显短于对照组(Ps<0.05-0.01)。睡眠效率降低、觉醒次数增多、NREM4和REM期睡眠缩短,以及进入REM睡眠时间缩短均与OSAHS患者神经认知功能损害显著相关。结论:OSAHS患者的认知功能存在广泛损害,且与其睡眠结构异常密切相关。
Objective: To investigate the relationship between neurocognitive function and sleep architecture in male patients with OSAHS. Methods: A case-control study was conducted. Sixty-six patients with OSAHS and 38 normal controls with matched age, gender and educational level completed MoCA, WMS, WCST ), Stroop Color Test (SCWT) and Epworth Sleepiness Scale (EES), and completed overnight polysomnography (PSG). Results: The scores of MoCA, WMS, WCST and SCWT in OSAHS group were significantly different from those in control group (P <0.05 or 0.001). OSAHS group EES score higher than the control group, sleep efficiency, NREM 2 and REM percentage was significantly lower than the control group, enter REM sleep time was significantly shorter than the control group (Ps <0.05-0.01). Reduced sleep efficiency, increased number of awakenings, shortened sleep in NREM4 and REM, and shortened REM sleep time were significantly associated with impaired neurocognitive function in OSAHS patients. Conclusion: The cognitive function of patients with OSAHS has extensive damage, and is closely related to the abnormality of sleep structure.