灭囊灵对实验性脑水肿大鼠模型的影响

• 作 者: 郑有顺 文磊 陈治水
• 机 构: 第一军医大学中医药研究所,解放军２１１医院中医科
• 出 处: 中药药理与临床
• 发表日期: 1998年03期
• 关键词: 醋氮酰胺 大鼠 脑血管通透性 模型组 脑组织含水量 脑血肿 治疗作用 脑水肿 伊文斯 鼠脑

实验性脑血肿诱发脑水肿的模型大鼠脑系数和造模侧脑组织含水量及伊文斯蓝（Ｅｖａｎ’ｓＢｌｕｅ，ＥＢ）含量在造模后高于正常对照组，以上改变随造模后时间的推移有所加重。灭囊灵高、低剂量及醋氮酰胺对以上病理改变均有一定的治疗作用，其中以灭囊灵高剂量组的作用最为明显，灭囊灵低剂量组与醋氮酰胺组的作用相当，但以上各治疗组均不能使造模大鼠的上述病理改变恢复至正常水平

Cerebral edema induced by experimental cerebral edema in rat brain coefficients and brain water content and brain water content of Evans blue (Evan’s Blue, EB) in the model after the higher than the normal control group, the above changes with the model after the time The passage of time has been aggravated. Capsule high, low dose and vinegaritamide on the above pathological changes have a certain therapeutic effect, of which the high dose of desmethin the most obvious role, the low dose of desmethin and acetazolamide group role quite, However, none of the above treatment groups were able to restore the above pathological changes of the model rats to normal levels