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目的探讨垂体强化核磁共振(MRI)对垂体柄阻断综合征(PSIS)的诊断价值并分析垂体MRI表现与垂体-靶腺功能损伤的相关性。方法选取PSIS患儿64例(PSIS组),同时选取正常儿童及青少年60例(对照组)。根据垂体MRI表现将PSIS组分为部分性垂体柄阻断(p PSIS)组和完全性垂体柄阻断(c PSIS)组。检测相关激素水平,分析MRI表现与缺乏的激素种类数目及严重程度的相关性。结果 PSIS组垂体核磁共振表现与功能损伤呈正相关。比较垂体-靶腺激素,c PSIS组缺乏的激素种类数目及严重程度均显著高于p PSIS组(P<0.01)。PSIS组男性(24例,年龄均大于15岁)性激素水平显著低于对照组(P<0.05),c PSIS组男性睾酮水平显著低于p PSIS组(P<0.01),其余性激素水平无显著差异。结论下丘脑-垂体区强化M RI可显示垂体柄的受损程度,可用于评估PSIS患儿垂体功能。
Objective To investigate the diagnostic value of pituitary enhanced MRI in the diagnosis of pituitary stalk obstruction syndrome (PSIS) and to analyze the correlation between pituitary MRI findings and pituitary-target gland dysfunction. Methods 64 cases of PSIS children (PSIS group) were selected, and 60 normal children and adolescents (control group) were selected. PSIS was divided into partial pituitary stalk block (p PSIS) group and complete pituitary stalk block (c PSIS) group according to pituitary MRI. Detection of relevant hormone levels, analysis of MRI performance and lack of hormone types and the severity of the correlation. Results PSIS showed pituitary nuclear magnetic resonance performance and functional impairment was positively correlated. Compared with p PSIS group (P <0.01), the number and severity of hormones lacking in pituitary-target gland hormone and c PSIS group were significantly higher than those in p PSIS group. The levels of sex hormones in PSIS group were significantly lower than those in control group (24 cases, age> 15 years) (P <0.05). The level of testosterone in male PSIS group was significantly lower than that in p PSIS group (P <0.01) . Conclusions Hypothalamus-pituitary enhancement M RI can show the extent of pituitary stalk damage and can be used to evaluate pituitary function in children with PSIS.