论文部分内容阅读
目的 :观察银杏叶醇提取物对异烟肼和利福平肝毒性的保护作用及其机制探讨。方法 :分别测定肝损害组和银杏叶醇提取物大、小剂量组小鼠的血清谷丙转胺酶 (SGPT)、肝指数、肝匀浆丙二醛 (MDA)含量、肝微粒体P4 50和线粒体Ca2 + ATP酶活性 ,以及肝病理检查 ,并与对照组比较。结果 :银杏叶醇提取物大、小剂量均可对抗异烟肼和利福平引起的MDA、SGPT、肝微粒体P4 50 的增高 (P <0 .0 5) ,以及对抗其引起的形态学改变 ;银杏叶醇提取物大剂量对抗其线粒体Ca2 + ATP酶活性的降低。结论 :银杏叶醇提取物可对抗异烟肼和利福平所致肝毒性。
Objective: To observe the protective effect of Ginkgo biloba alcohol extract on isoniazid and rifampicin hepatotoxicity and its mechanism. Methods: The levels of serum glutathione aminotransferase (SGPT), liver index and liver homogenate malondialdehyde (MDA) in liver injury group and Ginkgo biloba alcohol extract large and small dose groups were determined respectively. And mitochondrial Ca2 + ATPase activity, as well as liver pathological examination, and compared with the control group. Results: Ginkgo biloba ethanol extract could resist the increase of MDA and SGPT caused by isoniazid and rifampicin, and the increase of liver microsomal P450 (P <0.05), as well as against its induced morphological Change; Ginkgo biloba alcohol extract against its mitochondrial high dose of Ca2 + ATPase activity decreased. Conclusion: Ginkgo biloba alcohol extract can antagonize hepatotoxicity caused by isoniazid and rifampicin.