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糖皮质激素(glucocorticoid,GC)是临床最常用的药物之一,由于良好的抗炎、抗风湿、抗休克和免疫抑制作用而广泛用于风湿性疾病、呼吸系统疾病等的治疗,同时GC在骨重建过程中也发挥着重要的作用.然而长期应用GC会导致许多并发症,其中骨量丢失尤其是骨质疏松性骨质疏松(GIOP)是最为严重的并发症.凋亡对保持组织的健康和正常生长具有十分重要的意义,但异常的凋亡就可能造成机体损伤.基于细胞凋亡的形态特征和分子改变过程,有很多种方法可进行细胞凋亡的检测.近年来的研究发现成骨细胞是GC主要的作用靶点,GC主要是通过抑制成骨细胞介导的骨形成,造成了骨量的丢失,其中成骨细胞凋亡可能是GC抑制骨形成的主要环节,现就凋亡在GIOP中的作用及作用机制进行综述,为提高临床对GIOP的认识提供帮助.“,”Glucocorticoids (GC) is one of the most commonly used drugs.Because of its good anti-inflammatory,anti rheumatism,anti-shock and immunosuppression effects,it is widely used in the treatment of rheumatic diseases,respiratory diseases and other diseases.GC also plays an important role in bone remodeling.However,long-term application of GC can lead to many complications,among which includes bone loss,especially glucocorticoid-induced osteoporosis (GIOP),as the most serious complication.Apoptosis is very important in the maintenance of healthy and normal growth of tissue,but abnormal apoptosis may cause damage to the body.Based on morphological characteristics and molecular changes of apoptosis,there are many method to detect apoptosis.In recent years,studies have found that osteoblasts are the main target of GC.GC caused bone loss mainly by inhibiting bone formation,and the apoptosis of osteoblasts might be the main cause of GC inhibition of bone formation.This article reviews the role and mechanism of apoptosis in GIOP in order to help to improve the clinical knowledge of GIOP.