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核受体的作用极其广泛 ,类固醇生成因子 1(SF 1)和剂量敏感的性别转换综合征和先天性肾上腺发育不良症的关键基因 1(DAX 1)两种核受体家族是近年来发育内分泌学研究的热点之一 ,通过SF 1和DAX 1的动物模型及人类基因突变表现型阐述了在胚胎早期性发育和性分化中SF 1和DAX 1的作用可能通过相同途径相互拮抗 ,在垂体促性腺细胞和肾上腺能细胞中 ,两者在细胞及组织中的分布一致 ,通过下丘脑对垂体 性腺轴及垂体 肾上腺轴发育过程中不同时期的各个环节进行调控 ,本文对SF 1和DAX 1在内分泌器官发育过程中的分布、结构及其作用进行综述。
The role of nuclear receptors is extremely wide. Both nuclear receptor families, steroidogenic factor 1 (SF 1) and the dose-sensitive sex-switching syndrome and the key gene 1 (DAX 1) of congenital adrenal dysplasia, are endocrine and endocrine One of the hot topics in the field of study is that the effects of SF 1 and DAX 1 in the early development and sexual differentiation of embryos may be antagonized by the same pathway through the animal models of the SF 1 and DAX 1 and the phenotypes of human genetic mutations. Gonadal cells and adrenal cells, both in the distribution of cells and tissues in the same, through the hypothalamus of the pituitary gland axis and pituitary adrenal axis in various stages of development at various stages of regulation, the SF 1 and DAX 1 in the endocrine The distribution, structure and function of organ development are reviewed.