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最近证明纤维蛋白原水平(FV)是脑卒中和冠心病死亡的独立易患因素。本文试析FV和吸烟(单独或联合)对动脉粥样硬化性心血管疾病(CVD)发生率的影响。 Framingham试验组自1948年起每2年对5209例受试者进行随访检查,借以分析可疑易患因素与CVD发生率之间的关系。第10次随访检查时,47～79岁的1499(男662、女837)例受试者采血测定FV(Swaim和Feder法),剔除184例已患CVD者。其余1315(男554、女761)例随访14年,其间369(男192、女177)例受试者发生冠心病(202例次)、脑卒中(92例次)、心力衰竭或外周动脉病变。
Recent evidence of fibrinogen levels (FV) is an independent predisposing factor for stroke and coronary heart disease deaths. This article examines the impact of FV and smoking (either alone or in combination) on the incidence of atherosclerotic cardiovascular disease (CVD). The Framingham trial ran 5209 subjects every two years from 1948 on follow-up to analyze the relationship between suspicious predisposition and CVD prevalence. At the 10th follow-up visit, FV (Swaim and Feder methods) were collected from 1499 (662 male, 837 female) subjects aged 47-79 years and 184 were excluded from the CVD. The remaining 1315 cases (male 554, female 761) were followed up for 14 years. Among them, 369 (192 male and 177 female) patients had coronary heart disease (202 cases), stroke (92 cases), heart failure or peripheral artery disease .