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单链尿激酶型纤溶酶原激活物(scu-PA)是双链尿激酶型纤溶酶原激活物(tcu-PA)的先体,scu-PA被纤溶酶或其他激活物分解产生激活的tcu-PA,通过将纤溶酶原转化为纤溶酶,tcu-PA在纤维蛋白溶解和细胞外蛋白水解中起一定作用。scu-PA分裂也会引起失活。凝血酶分裂scu-PA可产生失活的tcu-PA,即tcu-PA/T,这一过程可使新鲜血凝块免于发生早期的纤维蛋白溶解,但在何种条件下体内会产生tcu-PA/T尚未明了。为证明scu-PA失活取决于凝血酶的产生这一假设,本研究对几种存在不同程度高凝血状态的患者进行研究,以分析tcu-PA/T水平和反映凝血酶产生水平的参数间的关系。
Single-chain urokinase-type plasminogen activator (scu-PA) is a precursor of double-stranded urokinase-type plasminogen activator (tcu-PA), scu-PA was generated by the decomposition of plasmin or other activators Activated tcu-PA, tcu-PA plays a role in fibrinolysis and extracellular proteolysis by converting plasminogen to plasmin. Scu-PA cleavage can also cause inactivation. Thrombin cleavage of scu-PA produces inactivated tcu-PA, tcu-PA / T, a process that renders fresh blood clots free of early fibrinolysis, but under what conditions the body produces tcu -PA / T is not yet clear. To demonstrate that the inactivation of scu-PA is dependent on the hypothesis that thrombin is produced, we studied several patients with varying degrees of high coagulation status to analyze tcu-PA / T levels and parameters that reflect thrombin generation Relationship.