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目的:探讨Podoplanin及CD34在口腔颌面部脉管畸形诊断中的意义。方法:收集30例病理诊断为脉管畸形的标本,进行HE染色,采用免疫组织化学方法观察Podoplanin和CD34的表达。结果:Podoplanin和CD34双重染色结果显示,淋巴管对Podoplanin有较好的阳性表达,呈现深褐色;而毛细血管对CD34有较好的阳性表达,呈现蓝色。结论:Podoplanin和CD34双重染色,在畸形血管和淋巴管中有较好的表达,能够辨别脉管畸形中的毛细淋巴管和毛细血管,可以作为组织学诊断的辅助。
Objective: To investigate the significance of Podoplanin and CD34 in the diagnosis of oral and maxillofacial vascular malformations. Methods: Thirty specimens of pathological diagnosis of vascular malformation were collected and stained with hematoxylin and eosin (HE). Immunohistochemistry was used to observe the expression of Podoplanin and CD34. RESULTS: The double staining of Podoplanin and CD34 showed that the lymphatic vessels had a good positive expression of Podoplanin, showing a dark brown color; while the capillaries showed a good positive expression of CD34 and showed a blue color. CONCLUSION: Podoplanin and CD34 double staining, which is well expressed in abnormal blood vessels and lymphatic vessels, can distinguish lymphatic vessels and capillaries in vascular malformations, and can be used as an aid in histological diagnosis.