论文部分内容阅读
目的探讨伽玛刀治疗功能性垂体腺瘤的效果并分析影响疗效的相关因素。方法回顾性分析我中心2006年1月~2010年4月伽玛刀治疗的获得完全随访的112例功能性垂体腺瘤患者的临床资料。以50%的等剂量曲线包绕靶区,给予边缘剂量10~25 GY,巨大腺瘤采用分次治疗。根据术后临床症状、肿瘤大小及激素水平评价疗效。结果随访12~64个月,平均30.5个月,其中临床症状缓解率为82.1%,肿瘤大小控制率为89.3%,激素水平控制率70.5%,3例出现垂体功能低下(2.6%),且伽玛刀治疗垂体腺瘤的疗效与肿瘤大小、边缘剂量、侵袭性有关。结论伽玛刀治疗功能性垂体腺瘤安全有效的方法,其疗效与肿瘤大小、侵袭性,边缘剂量有关。
Objective To investigate the effect of Gamma Knife in the treatment of functional pituitary adenoma and to analyze the related factors that influence the curative effect. Methods We retrospectively analyzed the clinical data of 112 patients with functional pituitary adenoma who underwent Gamma Knife therapy from January 2006 to April 2010 in our center. To 50% of the isodose curve around the target area, given the marginal dose of 10 ~ 25 GY, gigantic adenoma with fractional treatment. According to the clinical symptoms, tumor size and hormone levels evaluation of efficacy. Results The patients were followed up for 12 to 64 months with an average of 30.5 months. The rate of clinical symptom relief was 82.1%, tumor size control rate was 89.3%, hormone level control rate was 70.5%, and pituitary dysfunction was 2.6% The efficacy of the knife treatment of pituitary adenoma and tumor size, marginal dose, invasiveness related. Conclusion Gamma knife treatment of functional pituitary adenoma safe and effective method, the efficacy and tumor size, invasive, marginal dose.