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上皮-间质转化(EMT)是上皮细胞表型向间质细胞表型转变的过程,在肿瘤发生及其演变中发挥着重要的作用。近期研究表明,EMT在多种肿瘤的化疗耐药中发挥重要作用,而化疗药物也能增强肿瘤的恶性程度包括诱导EMT表型的产生。本文结合国内外最新报道,对EMT与肿瘤耐药关系的研究进展进行综述。
Epithelial-mesenchymal transition (EMT) is a phenotypic transition from the epithelial phenotype to stromal cells and plays an important role in tumorigenesis and progression. Recent studies have shown that EMT plays an important role in chemoresistance in a variety of tumors, and chemotherapeutic drugs can also enhance the malignancy of tumors, including the induction of EMT phenotype. In this paper, the latest reports at home and abroad, the progress of research on the relationship between EMT and tumor resistance are reviewed.