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地方性克汀病可影响全身骨骼的发育和形态,在手及腕部骨骼亦有一定表现;如骨骺出现延迟,碎裂不整,呈泡沫状改变,干骺端边緣不整,先期鈣化带增宽,掌骨干骺端肥大,腕骨堆挤及坏死,骺綫愈合延迟或不愈合等。此等改变在經甲状腺素治疗后可有某种程度的改善。以X綫观察这种改善情况,可作为判断治疗效果的客观指标。我們在該病流行区普查了4827人口,經临床实驗室(包括血清4碘酪氨酸的測定,甲状腺
Local Creutzfeldt-Jakob disease can affect the development and morphology of the body skeleton, bone and wrist in the hand and also have some performance; such as epiphyseal delay, fragmentation, showed a foam-like changes, metaphyseal edge is not the whole, with pre-calcification Wide, metacarpal metaplastic hypertrophy, crowding and necrosis carpal heap, epiphyseal line delay healing or non-union. These changes have some degree of improvement after thyroxine treatment. X-ray observation of this improvement can be used as an objective measure to determine the effect of treatment. We surveyed 4827 people in the endemic area of the disease and the clinical laboratory (including the determination of serum 4 iodine tyrosine, thyroid