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研究50Hz不同时间长度正弦交变电磁场(SEMFs)对大鼠骨生物力学性能的影响,筛选最佳作用时间。将40只雌性SD大鼠随机等分为5组:正常对照组和4个电磁场组(45 min组、90 min组、180 min组和270 min组)。电磁场组分别给予50Hz、0.1mT的电磁场作用,8周后行全身骨密度(BMD)、骨生物力学、骨组织形态学、显微计算机断层成像(micro-CT)系统和病理学检查。结果表明,实验组病理学检测未见异常;90min组全身骨密度、股骨最大载荷、弹性模量、屈服强度、骨小梁数量、厚度和面积百分比都显著高于对照组(P<0.01),骨小梁分离度显著低于对照组(P<0.01);其余各实验组部分指标显著高于对照组(P<0.05),部分指标无明显差异(P>0.05)。研究显示50Hz、0.1mT电磁场下,90min是增加SD大鼠BMD、改善骨组织微结构以及有效提升骨生物力学性能的最佳作用时间。
The effects of 50 Hz sinusoidal alternating electromagnetic field (SEMFs) of different lengths on the biomechanical properties of rat bone were studied, and the optimal time was screened. Forty female SD rats were equally divided into 5 groups: normal control group and 4 electromagnetic field groups (45 min group, 90 min group, 180 min group and 270 min group). Electromagnetic field were given 50Hz, 0.1mT electromagnetic field effect, 8 weeks after the whole body bone mineral density (BMD), bone biomechanics, bone histomorphology, micro-computed tomography (micro-CT) system and pathological examination. The results showed that there was no abnormality in the pathological examination of the experimental group. The BMD, maximum load, elastic modulus, yield strength, trabecular number, thickness and area percentage in the 90 min group were significantly higher than those in the control group (P <0.01) The trabecular separation was significantly lower than that of the control group (P <0.01). The remaining indexes of each experimental group were significantly higher than those of the control group (P <0.05). There were no significant differences in some indexes (P> 0.05). The results show that 50min and 0.1mT electromagnetic field, 90min is the best time to increase the BMD of SD rats, improve the microstructure of bone tissue and effectively improve the biomechanical properties of bone.