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患者男,36岁.会阴部反复红斑、斑块及溃疡1年余.患者既往有垂体瘤及尿崩症病史17年.皮肤科情况:左腹股沟见小片状浸润性斑块,中央浅溃疡.皮损组织病理示:真皮浅层见弥漫性淋巴细胞、嗜酸性粒细胞及组织样细胞浸润.增生的组织样细胞轻度异型,部分胞核呈肾型.免疫组织化学示:CD1a(+),S-1oo(+),CD68(+),Ki-67( ＜5％+).诊断:成人朗格汉斯细胞组织细胞增生症.“,”A 36-year-old male presented with recurrent erythemas,plaques and ulcers on the perineum for over 1 year.He had a 17-year medical history of hypophysoma and diabetes insipidus.Physical examination revealed an infiltrated plaque with central ulceration in the left groin.Histopathological examination showed diffuse infiltration of lymphocytes,eosinophilic granulocytes,and histiocytoid cells in the superficial dermis.The proliferative histiocytoid cells showed mild atypia,partly with kidney-shaped nuclei.Immunohistochemical examination showed that histiocytoid cells were positive for CD1 a,S-100 and CD68,and weakly positive for Ki-67 (＜5％ +).The diagnosis was adult Langerhans cell histiocytosis.