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目的:探讨大量输血方案(MTP)在治疗多发伤患者早期大量输血和预防凝血病中的效果。方法:回顾性分析2015年3月至2019年5月义乌市中心医院收治的多发伤患者117例，根据输血方案的不同分为对照组53例和观察组64例。对照组患者采取常规输血方案，观察组患者采取MTP输血方案。比较两组患者入院时及输血24 h后血常规及凝血功能变化、24 h内出血量及异体血液成分输入量、患者住院时间及病死率。结果:输血24 h后两组患者血红蛋白(Hb)、红细胞比容(Hct)、血小板计数(Plt)水平较入院时均显著升高[(112.73±12.73)g/L比(96.74±10.28)g/L，(115.28±19.27)g/L比(95.37±11.47)g/L，(39.72±5.21)%比(31.47±4.22)%，(39.10±4.97)%比(30.56±4.13)%，(220.93±54.28)×10n 9/L比(142.83±36.47)×10n 9/L，(216.87±64.03)×10n 9/L比(148.96±40.22)×10n 9/L；n t＝7.818、6.464、9.844、9.621、9.554、6.538，均n P0.05)；输血24 h观察组患者凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)时间较入院时均显著降低[(13.21±2.93)s比(16.28±4.26)s，(46.28±3.97)s比(54.37±6.42)s；n t＝4.705、8.574，均n P0.05]，输血24 h后观察组PT、APTT时间均明显短于对照组(n t＝4.344、8.006，均n P0.05]。两组患者24 h出血量、新鲜冰冻血浆(RBC)输入量差异均无统计学意义[(2 684.92±703.47)mL比(2 725.86±810.32)mL，(17.28±3.74)U比(17.02±2.95)U；n t＝0.293、0.411，均n P>0.05]，观察组患者红细胞悬液(PF)输入量以及PF∶RBC比例均显著高于对照组[(9.28±3.27)U比(6.29±3.18)U，(0.55±0.12)比(0.39±0.10)；n t＝4.985、7.733，均n P0.05]. The input amount of red blood cell suspension(PF) and the ratio of PF: RBC in the observation group were significantly higher than those in the control group[(9.28±3.27)U vs.(6.29±3.18)U, (0.55±0.12) vs.(0.39±0.10),n t=4.985, 7.733, all n P<0.05]. The observation group had significantly lower SOFA scores and ICU stays compared with the control group[(5.93±1.64)points vs.(7.28±2.10)points, (7.21±1.85)d vs.(9.10±2.37)d,n t=3.814, 4.732, all n P<0.05], and the mortality rate in the observation group was significantly lower than that in the control group[6.25%(4/64) vs.20.75%(11/53), χn 2=5.457, n P<0.05].n Conclusion:The standardized rescue strategy of a large number of blood transfusion treatment schemes and the early proportion of components of blood products (erythrocyte suspension, fresh frozen plasma, platelets) can significantly improve the coagulation function of patients with multiple injuries, reduce the incidence of coagulopathy and help reduce the fatality rate of major bleeding, which is worthy of clinical promotion.