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目的探讨血清胱抑素C(CysC)和尿微量白蛋白(MA)联合检测对糖尿病早期肾损伤的诊断价值。方法采用免疫比浊方法分别检测91例2型糖尿病患者和40例健康体检者(为对照组)的血清CysC和尿MA水平。结果糖尿病组患者血清CysC和尿MA水平均显著高于对照组,差异有统计学意义(t值分别14.46、24.96,P<0.01),而糖尿病患者血清CysC水平与尿MA水平呈正相关(r=0.459,P<0.01),糖尿病患者联合检测的阳性率明显高于单项检测,差异有统计学意义(χ2=8.19,P<0.05)。结论血清CysC和尿MA是糖尿病患者早期肾损伤的敏感指标,联合检测对及时准确地诊断糖尿病早期肾损伤有重要的临床应用价值。
Objective To investigate the diagnostic value of combined detection of serum cystatin C (CysC) and urinary microalbumin (MA) in the early stage of diabetic renal injury. Methods The levels of serum CysC and urinary MA in 91 type 2 diabetic patients and 40 healthy controls (control group) were detected by immunoturbidimetry. Results The levels of serum CysC and urinary MA in diabetic patients were significantly higher than those in the control group (t = 14.46, 24.96, respectively, P <0.01), but there was a positive correlation between serum CysC and urinary MA in diabetic patients (r = 0.459, P <0.01). The positive rate of joint detection in diabetic patients was significantly higher than that of single test (χ2 = 8.19, P <0.05). Conclusions Serum CysC and urinary MA are sensitive indicators of early renal injury in diabetic patients. Combined detection has important clinical value in diagnosing early diabetic renal injury in time.