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目的：研究神经外科导航下锁孔手术的麻醉效果；方法选择2013年1月～2014年6月在我院接受神经外科导航下锁孔手术治疗的患者88例，分为瑞芬太尼组与芬太尼组，瑞芬太尼组以瑞芬太尼麻醉，芬太尼组以芬太尼组麻醉；结果两组患者手术时间比较，差异无统计学意义（P＞0.05）；瑞芬太尼组异丙酚使用量、停药到拔管时间均显著低于芬太尼组，差异具有统计学意义（P＜0.05），且两组患者术后不良反应情况比较差异无统计学意义（P＞0.05）；结论瑞芬太尼替代芬太尼应用于神经外科导航下锁孔手术麻醉效果显著，值得应用于临床。“,”Objective To study the anesthesia effect of Department of neurosurgery navigation keyhole operation;Methods Select 2013 January~2014 June treated 88 cases of keyhole operation navigation of patients who underwent Department of neurosurgery in our hospital, divided into remifentanil group and fentanyl group, remifentanil group with remifentanil anesthesia, fentanyl group with fentanyl anesthesia; Results Comparison group;two groups of patients with operation time, no significant difference (P>0.05);remifentanil propofol group usage, stops the medicine to extubation time was significantly lower than that of fentanyl group, with statistical difference (P0.05); Conclusion Remifentanil fentanyl used in Department of neurosurgery navigation under keyhole operation anesthesia effect is significant, worthy of clinical application in the.