A review:biosynthesis of plant-derived labdane-related diterpenoids

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Plant-derived labdane-related diterpenoids(LRDs)represent a large group of terpenoids.LRDs possess either a lab-dane-type bicyclic core structure or more complex ring systems derived from labdane-type skeletons,such as abietane,pimarane,kaurane,etc.Due to their various pharmaceutical activities and unique properties,many of LRDs have been widely used in pharma-ceutical,food and perfume industries.Biosynthesis of various LRDs has been extensively studied,leading to characterization of a large number of new biosynthetic enzymes.The biosynthetic pathways of important LRDs and the relevant enzymes(especially diterpene synthases and cytochrome P450 enzymes)were summarized in this review.
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