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目的观察向心性肥胖患者的8-异前列腺素(8-iSo-PGF2α)水平及其与胰岛素抵抗的关系。方法筛选糖耐量正常的向心性肥胖患者(包括胰岛素抵抗与无胰岛素抵抗者)及正常对照组。分别测定血清8-iso-PGF2α,丙二醛(MDA),游离脂肪酸(FFA)等。结果向心性肥胖组8-iso-PGF2α、MDA、胰岛素抵抗指数(HOMA-IR)、FFA均显著高于对照组(P<0.05)。8-iso-PGF2α差异最显著(P<0.01),且与FFA、BMI及甘油三酯(TG)呈显著正相关。胰岛素抵抗亚组的8-iso-PGF2α水平显著高于无胰岛素抵抗亚组。多元回归分析显示,8-iso-PGF2α与HOMA-IR相关性最强。结论糖耐量正常的向心性肥胖患者氧化应激增强,且氧化应激是胰岛素抵抗的重要危险因素,循环中8-iso--PGF2α水平能更好地反映其程度。
Objective To observe the level of 8-iso-prostaglandin (8-iSo-PGF2α) and its relationship with insulin resistance in patients with central obesity. Methods The patients with central obesity with normal glucose tolerance (including those with insulin resistance and without insulin resistance) and the normal control group were screened. Serum 8-iso-PGF2α, malondialdehyde (MDA), free fatty acid (FFA) and so on were measured. Results The levels of 8-iso-PGF2α, MDA, HOMA-IR and FFA in patients with central obesity were significantly higher than those in controls (P <0.05). The difference of 8-iso-PGF2α was the most significant (P <0.01), and positively correlated with FFA, BMI and triglyceride (TG). Insulin resistance subgroup of 8-iso-PGF2α levels were significantly higher than those without insulin resistance subgroup. Multivariate regression analysis showed that 8-iso-PGF2α had the highest correlation with HOMA-IR. Conclusions Oxidative stress is increased in patients with central obesity with normal glucose tolerance and oxidative stress is an important risk factor of insulin resistance. The level of 8-iso-PGF2α in circulation can reflect its degree better.