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目的:探讨和研究外周血造血干细胞移植治疗血液病的临床效果。方法:回顾性分析22例血液病患者的临床资料,其中4例采用异基因外周血造血干细胞移植,18例采用自体外周血造血干细胞移植。结果:以上患者均能成功造血重建,未发生严重移植物抗宿主病,无移植相关死亡,随访2年,自体基因移植组患者3例因复发死亡,异基因移植组患者无复发或死亡。结论:外周血造血干细胞移植对于血液病的治疗有着造血重建快,移植相关并发症和死亡率低,是治疗血液病的一种安全有效的方法。
Objective: To investigate and study the clinical effect of peripheral blood hematopoietic stem cell transplantation in the treatment of hematological diseases. Methods: The clinical data of 22 cases of hematological diseases were retrospectively analyzed. Among them, 4 cases were allogeneic peripheral blood stem cell transplantation and 18 cases were treated with autologous peripheral blood stem cell transplantation. Results: All of the above patients were successful in hematopoietic reconstitution. There was no severe graft-versus-host disease and no graft-related death. Three years after autologous gene transplantation, 3 patients died of recurrence and none of allogeneic transplantation patients had recurrent or death. CONCLUSION: Peripheral blood stem cell transplantation is a safe and effective method for the treatment of hematological diseases. It has the advantages of fast hematopoietic reconstitution, low complications related to transplantation and low mortality.