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以子宫颈鳞状上皮细胞的细胞核浓缩、核周围间隙增大为特点的细胞凹陷现象,被认为是人乳头瘤病毒感染的指征。1987年这种相同的形态学变化首次报道见于膀胱肿瘤。本文对160例女性膀胱肿瘤标本,其中47例同时具有子宫颈组织学和细胞学资料,进行观察研究,旨在探讨这种形态学变化与人类乳头瘤病毒和膀胱肿瘤之间的病原学关系。研究所采用的资料,经组织学分类,分别为乳头状瘤,非侵润性乳头状癌(包括原位癌),侵润性乳头状癌;按WHO分级方法分为Ⅰ～Ⅲ级。观察结果显示,94例膀胱癌中
The phenomenon of cell degeneration, which is characterized by the concentration of nuclei in the cervical squamous epithelium and the increase of the clearance around the nucleus, is considered as an indication of human papillomavirus infection. This same morphological change was first reported in bladder tumors in 1987. In this paper, 160 cases of female bladder tumor specimens, including 47 cases of both cervical histology and cytology data were observed and studied to explore this morphological changes and human papillomavirus and bladder tumor between the etiological relationship. The data used in the study, histological classification, were papilloma, non-invasive papillary carcinoma (including carcinoma in situ), invasive papillary carcinoma; according to WHO classification method is divided into Ⅰ ~ Ⅲ grade. Observations show that 94 cases of bladder cancer