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透明质酸酶 (Hyase)和透明质酸 (HA)是细胞外基质(ECM)的重要组成部分 ,Hyase通过降解透明质酸破坏基底膜结构的完整性 ,与炎症、疤痕形成、肝纤维化形成以及肿瘤细胞的扩散联系紧密。人类Hyase编码基因有 6种。本文对这 6种Hyase相关基因以及透明质酸酶与肿瘤的研究现状作一综
Hyase and hyaluronic acid (HA) are important components of the extracellular matrix (ECM). Hyase damages the integrity of the basement membrane structure by degrading hyaluronic acid and is associated with inflammation, scarring, and fibrosis As well as the proliferation of tumor cells. There are 6 human Hyase encoding genes. This article summarizes the current status of these 6 Hyase-related genes and hyaluronidase and tumor