论文部分内容阅读
Purpose: To present and test a new interpretative concept, the nerve fibre lay er symmetry test (NST), for computerized evaluation of retinal nerve fibre layer thickness (RNFLT) as measured by optical coherence tomography (OCT) in glaucoma . Methods: The NST concept was constructed and tested in a pilot study. A total of 32 healthy and 40 age-matched glaucomatous eyes were included and examined b y OCT, computerized perimetry, RNFL/disc photography, tonometry and a general op hthalmologic examination. Results: The observed NST sensitivity and specificity were high, at 38/40 eyes (95%)-and 32/32 eyes (100%), respectively, and 40/40 eyes (100%), and 31/32 eyes (97%), respectively, when correcting the OCT RNFL T measurement for the influence of variability in image signal/quality. The NST sensitivity was 8-10%higher than the single most sensitive traditional OCT RNF LT parameter; this difference was not statistically significant in this small sa mple. Conclusion: The NST showed high specificity and sensitivity for detection of RNFLT attenuation indicating early to severe glaucoma. Although promising, th e NST needs to be further developed and validated in larger study samples and in patients with various stages of glaucomatous damage.
Purpose: To present and test a new interpretative concept, the nerve fiber lay er symmetry test (NST), for computerized evaluation of retinal nerve fiber layer thickness (RNFLT) as measured by optical coherence tomography (OCT) in glaucoma. Methods: The NST concept was constructed and tested in a pilot study. A total of 32 healthy and 40 age-matched glaucomatous eyes were included and examined by OCT, computerized perimetry, RNFL / disc photography, tonometry and a general op hthalmologic examination. sensitivity and specificity were high, at 38/40 eyes (95%) - and 32/32 eyes (100%), respectively, and 40/40 eyes (100%), and 31/32 eyes when correcting the OCT RNFL T measurement for the influence of variability in image signal / quality. The NST sensitivity was 8-10% higher than the single most sensitive traditional OCT RNF LT parameter; this difference was not substantially said in this small sa mple. Conclusion: The NST showed high speci ficity and sensitivity for detection of RNFLT attenuation indicating early to severe glaucoma. Although promising, th e NST needs to be developed and validated in larger study samples and in patients with various stages of glaucomatous damage.