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目的：评价呕必亭１ 天给药预防含顺铂分次给药中度致呕的联合化疗所致呕吐的可行性，与枢丹比较，观察两药的止吐疗效和毒性。方法：４０ 例接受含顺铂２０ ～２５ｍｇ／ｍ２／日，连续３ 天的联合化疗患者，采用随机、交叉、自身对照方法，分别给予呕必亭５ｍｇ，静注，第１ 天；或枢丹８ｍｇ，静注，第１ ～３ 天。结果：对急性呕吐，呕必亭和枢丹有效率分别为９２５ ％ 和９５０％ ，完全控制率分别为９２５％ （３７／４０） 和８００％ （３２／４０） 。对延迟性恶心、呕吐（ 第２ ～５天） 完全控制率和有效率亦相近，差异无统计学意义（ Ｐ＞ ００５） 。两药的副作用均较轻微。结论：呕必亭５ｍｇ １ 天给药与枢丹８ｍｇ ３ 天给药止呕吐疗效相似。呕必亭１ 天给药方便且费用低，但仍需评价和发展使用方便、费用适宜且对延迟性恶心、呕吐有效的新方法
OBJECTIVES: To evaluate the feasibility of vomiting for one day to prevent vomiting caused by combination chemotherapy with moderate vomiting with cisplatin divided doses, and to compare the antiemetic efficacy and toxicity of both drugs with Gandan. METHODS: Forty patients who received combination chemotherapy with cisplatin 20-25mg/m 2 /day for 3 consecutive days were randomized, crossover, and self-control methods. They were given vomiting 5mg, intravenously, on the first day; or Gandan 8mg, intravenous injection, 1st to 3rd days. RESULTS: For acute vomiting, the efficacies of voibidine and chudan were 92.5% and 95.0%, respectively, and the complete control rates were 92.5% (37/40) and 80.0% (32/40), respectively. . The complete control rate and effective rate of delayed nausea and vomiting (2nd to 5th days) were also similar, with no statistically significant difference (P> 005). Both drugs have mild side effects. CONCLUSIONS: The efficacy of vomiting with 5 mg 1 day of dosing was similar to that of 8 mg of dandan 8 mg for 3 days. Vomiting kiosks are easy to administer in one day and cost is low, but there is still need to evaluate and develop new methods that are convenient to use, cost-effective and effective for delayed nausea and vomiting.