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十几年前曾有人报告在动物和人的下丘脑正中隆起提取液中存在类促性腺激素的生物活性。近来Ema-nuele等人观察到,在大鼠脑内散在地分布有类LH肽的免疫活性。在切除垂体后,该物质仍然存在。说明大鼠脑中的类LH物质来源于脑,而不可能来源于垂体。传统的观念认为,下丘脑控制腺垂体的激素分泌,而腺垂体激素又可通过短反馈的途径作用于下丘脑,调节其机能。但上述资料表明,下丘脑的类LH物质并非来自腺垂体,那么它对腺垂体的LH释放是否具有调节作用呢?Emanuele等对这一问题进行了研究。他们分别测定了成年雌性大鼠动情周期各期和去卵巢或假手术雌鼠下丘脑、腺垂体及血清中的LH含量。结果观察到,下丘脑中的LH含量随周期而变化,于
More than a decade ago, it was reported that the presence of gonadotropin-like bioactivity in the hypothalamic median elevated extract of animals and humans. Recently, Ema-nuele et al observed that the LH-like peptide immunologically distributed in the rat brain. After removal of the pituitary, the substance still exists. This shows that the LH-like substances in the rat brain are derived from the brain, but not from the pituitary gland. The traditional concept that the hypothalamus control the secretion of pituitary gland, and pituitary hormones in turn through a short feedback pathways acting on the hypothalamus, regulating its function. However, the above data suggest that LH-like substances in the hypothalamus do not originate from the pituitary gland, so does it regulate the LH release from the pituitary gland? Emanuele et al. They measured the adult female rat estrus cycle and ovariectomized or sham-operated female hypothalamus, pituitary and serum LH levels. The results observed in the hypothalamus in the LH content changes with the cycle, at