Artemisinin protected human SY5Y and hippocampal neurons from H2O2-induced oxidative damage through

• 作 者: JIANG Yi-zhou ZHAO Xia ZHENG W
• 机 构: FacultyofHealthSciences
• 出 处: 中国药理学与毒理学杂志
• 发表日期: 2018年9期
• 关键词: ARTEMISININ hydrogen PEROXIDE SHSY5Y cells HIPPOCAMPAL neurons AMPK PATHWAY
• 基金项目: National Natural Science Foundation of China(31771128),the University of Macau (MYRG2016-00052-FHS,MYRG2018-00134-FHS),Science and Technology Development Fund (FDCT)of Macao (FDCT 021/2015/A1,016/2016

Oxidative stress is one of the main causes of neurodegenerative diseases such as Alzheimer disease (AD). Our previous studies have shown that artemisinin, a anti-malaria Chinese medicine, with neuroprotective effect, however, the antioxidative effect of a