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GnRHa诱发排卵的作用依赖于开始给药的时间,在刺激周期早卵泡期给药,GnH分泌骤增,对卵泡募集和发育有益;于上周期的黄体期开始给药,则会导致功能性低GnH性腺功能低下状态(降调节),这使开始诱发排卵的时间有很大的伸缩性。GnRHa降调节对下个周期诱发排卵中卵巢反应性的影响问题一直未得解决,本文就此问题进行探讨。 在18个月内对165名年龄<40岁,CC反应正常且已证实有排卵周期妇女进行助孕治疗。在诱发排卵前于黄体期开始用Leuprolide acetate(LA)1mg/日Sc,LA的预治疗期限各患者不一致,有
The role of GnRHa in triggering ovulation depends on the time of the start of administration, administration during the early follicular phase of the stimulatory cycle, and surge in GnH secretion, which is beneficial for follicle recruitment and development; administration at the beginning of the upper luteal phase results in a less functional GnH hypogonadal status (downregulation), which makes the time to initiate ovulation has a great flexibility. The effect of GnRHa down regulation on the ovarian response induced by ovulation in the next cycle has not been solved yet. This article will discuss the problem. Within 18 months, 165 pregnant women <40 years of age with normal CC response and fertile ovulation cycles were enrolled. Before induction of ovulation in the luteal phase with Leuprolide acetate (LA) 1mg / day Sc, LA pre-treatment period of the inconsistent patients, there