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胡黄连(Picrorhiza kurroa)根及根茎中分离出来的含有胡黄连苦甙Ⅰ(Picroside—Ⅰ)和胡黄连甙(Kutkoside)的环烯萜甙混和物,具有保肝活性。而胡黄连苦甙Ⅰ和胡黄连甙以1:1.5的比例混合组成的标准制剂Picroliv,经药理、生化和组织学参数表明,具有显著的保肝活性。Picroliv对清醒大鼠和麻醉豚鼠有剂量依赖性的利胆效应,6和12mg/Kg时效应最大,并且比相同剂量的水飞蓟素这一保肝剂的效应要高得多。胆汁
The croconazole-containing mixture of Picroside-I and Kutkoside isolated from roots and rhizomes of Picrorhiza kurroa has hepatoprotective activity. The Picroliv, a standard preparation consisting of a mixture of berberine I and berberine I at a ratio of 1:1.5, showed significant hepatoprotective activity through pharmacological, biochemical, and histological parameters. Picroliv had a dose-dependent choleretic effect on conscious rats and anesthetized guinea pigs, with the greatest effect at 6 and 12 mg/Kg and much higher than the same dose of silymarin, the hepatoprotectant. bile