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目的 探讨肺鳞癌中MMP - 2的表达水平与肿瘤侵袭转移性的关系 ,研究在肺鳞癌中MMP - 2与 p5 3蛋白的相互关系。方法 应用免疫组化法 (SP法 )检测 5 0例肺鳞癌患者术后的石蜡包埋标本中MMP - 2、p5 3的表达情况。结果 MMP - 2在肺鳞癌组织中呈高表达 (76 .0 % ) ,MMP - 2的表达与肿瘤大小、分化程度、淋巴结转移明显相关 ,而与肿瘤部位、患者年龄无关。MMP - 2过度表达与 p5 3基因的突变有关。结论 MMP - 2的表达与肺鳞癌的侵袭转移性有关。p5 3基因突变后MMP - 2表达增强
Objective To investigate the relationship between the expression of MMP - 2 and tumor invasion and metastasis in squamous cell carcinoma of the lung (Squamous cell carcinoma of the lung) and to investigate the relationship between the expression of MMP - 2 and p5 3 in squamous cell carcinoma of the lung. Methods Immunohistochemistry (SP method) was used to detect the expression of MMP - 2 and p5 3 in paraffin - embedded specimens of 50 patients with squamous cell carcinoma of the lung. Results The expression of MMP - 2 in lung squamous cell carcinoma was high (76.0%). The expression of MMP - 2 was correlated with tumor size, differentiation and lymph node metastasis, but not with tumor location and patient ’s age. The overexpression of MMP - 2 is related to the mutation of p5 3 gene. Conclusion The expression of MMP - 2 is related to the invasion and metastasis of squamous cell lung cancer. The expression of MMP - 2 is enhanced after p5 3 gene mutation