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目的 探讨HGV感染与肝损伤的关系。方法 检测442例各类肝病患者的甲～戊和庚型肝炎病毒血清学标志,其中154例为HGV和HBV感染者。对单独HGV感染、HGV和HBV重叠感染及单独HBV感染者的临床资料进行对比分析。结果 21例单独HGV感染者中有9例(4286%)肝功能轻度异常。单独HGV感染与HGV和HBV重叠感染比较,肝功能异常程度无显著性差异;而重叠感染与单独HBV感染比较,肝功能异常率(3729%对9865%)和重型肝炎发生率(169%对1622%)后组均超过前组,差异有显著性(P分别为<005和<001)。结论 HBV感染可致轻度肝损伤;乙肝患者重叠HGV感染后有使病情减轻之势。
Objective To investigate the relationship between HGV infection and liver injury. Methods The serological markers of hepatitis A and E and hepatitis E in 442 cases of various liver diseases were detected, of which 154 cases were HGV and HBV infection. The clinical data of HGV infection, HGV and HBV overlap infection and HBV infection alone were compared. Results Nineteen of 21 HGV patients (4286%) had mild liver dysfunction. HGV infection alone had no significant difference in abnormal liver function compared with HGV and HBV over-infection. However, the rates of abnormal liver function (3729% vs 9865%) and severe hepatitis (169% vs 1622 %) After the group than the former group, the difference was significant (P respectively <005 and <001). Conclusions HBV infection can cause mild liver injury. Hepatitis B patients with overlapping HGV infection may alleviate the disease.