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目的探讨老年肺结核采用抗结核药物治疗不良反应及防治。方法选取100例老年肺结核采用抗结核药物治疗出现不良反应的病例,均为我院2012年1月至2014年1月收治,分析不良反应原因,并制定防治措施。结果患者此次研究中患者出现的不良反应主要包括过敏反应、消化系统以及神经系统方面的不良反应、肝脏功能损伤,不良反应发生率方面无显著性差异(P>0.05)。积极防治,临床症状全部消失;结核空洞也出现了不同程度的减小,吸收的结核病灶在1/3以上症状出现明显好转的患者有95例,其余5例患者因出现咳血不止的情况治疗无效死亡。结论针对老年肺结核患者,在应用抗结核药物治疗时,需对不良反应产生原因进行分析,对药物剂量和药物方案加以调整,以降低不良事件率,保障临床安全性,对提高疾病防控预后有非常重要的意义。
Objective To investigate the treatment of adverse reactions and prevention and treatment of elder pulmonary tuberculosis with anti-tuberculosis drugs. Methods Selected 100 cases of elderly patients with tuberculosis treated with anti-TB drugs adverse reactions were treated in our hospital from January 2012 to January 2014 were admitted to analyze the causes of adverse reactions and to develop prevention and treatment measures. Results The patients in this study had adverse reactions including allergic reaction, adverse reactions of digestive system and nervous system, liver dysfunction and incidence of adverse reactions. There was no significant difference (P> 0.05). Active prevention and treatment, all clinical symptoms disappear; tuberculosis cavity also decreased to varying degrees, absorption of tuberculosis lesions in more than 1/3 significantly improved in 95 patients, the remaining 5 patients due to hemoptysis more than the treatment Invalid death. Conclusion For elderly patients with pulmonary tuberculosis, the application of anti-TB drugs, the need to analyze the causes of adverse reactions, the drug dose and drug regimens to be adjusted to reduce the adverse event rate to protect the clinical safety of disease prevention and control to improve the prognosis of Very important meaning.