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作者报告50例非洲儿童急性阿米巴痢疾用甲硝磺酰咪唑的治疗效果。儿童年龄在4个月到11岁之间,其中15例营养不良,25例严重营养不良,5例严重营养不良兼有发育不全,仅5例营养较好。全部病儿均住院治疗并观察至少28天。25例用甲硝磺酰咪唑50毫克/公斤/天,早晨一次顿服,疗程3天。由于上述疗法的疗效不够满意,因此另25例改用60毫克/公斤/天的剂量,疗程仍为3天。治疗开始后的6、14、21、28天各进行大便检验,平均每例检验大便14次。结果:第1组25例中6例失败,治疗完成后仍查见阿米巴滋养体或包囊,其中1例在治后31天出现急性痢疾症状并在大便中找到溶组织内阿米巴,余5例均无症状但大便中有溶组织内阿米巴包囊。这6例再经二氯散1个疗程后阿米巴包囊消失。第2组除1例外全部治愈。未愈的1例治后症状消失,仅粪便中仍有阿米
The authors report the treatment of methamphetamine in 50 children with acute amoebic dysentery in Africa. Children aged 4 months to 11 years of age, of which 15 cases of malnutrition, 25 cases of severe malnutrition, malnutrition with both cases of dysplasia, only 5 cases of better nutrition. All sick children were hospitalized and observed for at least 28 days. 25 cases with methyl sulfonyl imidazole 50 mg / kg / day, a morning meal service, treatment for 3 days. Because of the curative effect of the above treatment is not satisfactory, so another 25 patients switched to 60 mg / kg / day dose, the course of treatment is still 3 days. Stool tests were performed on days 6, 14, 21 and 28 after the start of treatment, with an average of 14 stools per case. Results: In the first group of 25 cases, 6 cases failed. After treatment, the amoebic trophozoites or cysts were still detected. Among them, 1 case showed symptoms of acute dysentery on the 31st days after treatment and found in the stools. , More than 5 cases were asymptomatic, but there is dissolved tissue within the stool amoeba cyst. This six cases and then after two cycles of dichlorvos amimba cyst disappeared after a course of treatment. Group 2 except 1 exception were all cured. Unhealed in 1 case of symptoms disappeared, there is still only amoeba in the stool