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大骨节病(Kasochin——Beek disase)自1644年我国安泽县志记载以来作为疾病被人们认识已有300多年历史。欧洲人俄国官吏尤伦斯基在1844年于乌洛夫河两岸观察到此病。1857～1862年Kasochin医生在患区进行了调查,距今也有130年左右的历史。在这130年的研究过程中,先驱者们的大量工作,对揭示大骨节病的病因作出了有益的贡献。为我们在当代在新的层次上认识大骨节病的病因奠定了基础。然而,由于具有时代特征的科学技术发展水平的限制,致使19世纪甚至在本世纪50年代以前,对揭示大骨节病真正的病因几乎是不可能的。在此以前先驱者们的工作是有益的,但对大骨节病病因任何全面的论汪,却是徒劳的,因为时机尚未成熟。当时是处在生物化学尚未成熟到能为分子水平的骨代谢提供足够的知识的阶段。只有近20年来,知识处于爆炸性发展
Kasochin - Beek disase has been recognized for more than 300 years as a disease since the record of Anze County in China in 1644. The European Russian official Ullensky observed the disease on both sides of the Oulov River in 1844. From 1857 to 1862, Dr. Kasochin conducted a survey in the affected area, about 130 years ago. During these 130 years of research, a great deal of work by pioneers made a useful contribution to revealing the etiology of Kashin-Beck disease. This laid the foundation for us to recognize the etiology of Kashin-Beck disease on a new level in the contemporary era. However, due to the limitation of the level of development of science and technology with the characteristics of the times, it is almost impossible to reveal the real cause of Kaschin-Beck disease in the 19th century or even before the 1950s. Prior to this pioneer work is useful, but any comprehensive discussion of the cause of Kashin-Beck disease Wang, but in vain, because the timing is not yet ripe. It was at a time when biochemistry was not yet mature enough to provide enough knowledge of molecular metabolism at the bone level. Only in the past 20 years has the explosive growth of knowledge