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临床上难以肯定渐进性感音性耳聋的确切病因,除年龄因素外,既往史中应用耳毒药物、接触噪声环境和内耳疾病等均可导致听觉损害。在多种哺乳动物中已证实年龄与耳蜗毛细胞缺失有关,其最早始于耳蜗基底转,逐渐向蜗尖发展。先是外毛细胞受累,继后内毛细胞亦发生退行性变。对老年耳蜗功能方面的研究尚不多,本文用向前掩蔽的方法,变动±100dB的特种频率技术,连续测定3月龄和22月龄鼠的听脑干反应听阈。此外还分析了长期饮酒的22月龄鼠的听阈。鉴于鼠对低于1～2KHz的
Clinically difficult to determine the exact cause of progressive sexual acoustic deafness, in addition to age factors, the history of the application of ototoxic drugs, contact with the noise environment and inner ear disease can lead to hearing loss. In a variety of mammals have been proven age and cochlear hair cell loss, the earliest beginning in the cochlea basal turn, and gradually to the tip of the toe. First, the outer hair cells involved, followed by degeneration of the inner hair cells also occur. There is not much research on the cochlear function in the elderly. In this study, the auditory brainstem response thresholds of 3-month-old and 22-month-old mice were continuously measured by the method of forward masking and the special frequency of ± 100 dB. In addition, the long-term drinking 22-month-old rat’s hearing threshold was analyzed. Given the mouse pairs below 1 ~ 2KHz