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组织型纤维蛋白溶酶原活化剂(t-pt)的一半剂量与链激酶联用,其疗效与全剂量的t-pt相同。这是根据对这两种用药方案的多中心比较试验结果得出的。在研究中,216名患者(在心肌梗塞6小时内)在一小时内给予t-pt 50mg和链激酶1.5百万个国际单位或3小时内给予t-pt的常规量(100mg)。肝素和阿斯匹林用药方案仍保留。
One-half of the tissue-type plasminogen activator (t-pt) was used in combination with streptokinase for the same efficacy as the full dose of t-pt. This is based on the results of a multi-center comparison of these two regimens. In the study, 216 patients (within 6 hours of myocardial infarction) were given t-pt 50 mg and streptokinase 1.5 million international units in one hour or a conventional amount of t-pt given in 3 hours (100 mg). Heparin and aspirin regimens remain.