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目的:探讨综合干预对肥胖2型糖尿病胰岛素抵抗的影响。方法:将160例肥胖2型糖尿病的患者随机分为综合干预组与对照组各80例,综合干预组采用个体化饮食、运动与健康教育等干预手段,对照组采用一般常规护理。比较2组入组时及3、6个月后的血糖、血脂、血压、腰围(WC)、体重指数(BMI)、胰岛素抵抗指数。结果:综合干预组与对照组患者的空腹血糖、餐后血糖、糖化血红蛋白、血脂、体重指数均有下降(P<0.05),干预组下降幅度更明显(P<0.01)。结论:个体化综合干预可以有效改善肥胖2型糖尿病患者的血糖和血脂,减轻胰岛素抵抗。
Objective: To investigate the effect of comprehensive intervention on insulin resistance in obese type 2 diabetic patients. Methods: A total of 160 patients with obese type 2 diabetes were randomly divided into the intervention group and the control group, with 80 cases in each group. The intervention group was treated with individual diet, exercise and health education, and the control group was treated with general nursing. Blood glucose, blood lipids, blood pressure, waist circumference (WC), body mass index (BMI) and insulin resistance index were compared between the two groups when they were enrolled. Results: The fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, blood lipids, body mass index decreased in the intervention group and the control group (P <0.05), and decreased more significantly in the intervention group (P <0.01). Conclusion: Individualized comprehensive intervention can effectively improve blood glucose and blood lipids in obese type 2 diabetic patients and reduce insulin resistance.