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目的:探讨新型冠状病毒肺炎（COVID-19）患者初诊临床特征及胸部高分辨率CT(HRCT）影像表现。方法:回顾性搜集2020年1月20日至28日武汉大学人民医院经临床及核酸检测确诊的141例COVID-19患者，男77例，女64例，中位年龄49(9, 87）岁。分析141例COVID-19患者的临床特征、实验室检查指标以及胸部HRCT影像学表现。结果:141例COVID-19患者实验室检查发现白细胞计数降低38例（26.95%）、淋巴细胞比率降低71例（50.35%）。141例COVID-19患者中发热（>37.5 °C) 139例（98.58%）、咳嗽106例（75.18%）、头痛11例（7.80%）、咳痰41例（29.08%）、胸闷93例（65.96%）、呼吸道以外症状主要有腹泻等4例（2.84%）。141例COVID-19患者HRCT均有异常，52例（36.88%）胸部HRCT图像表现为磨玻璃影（GGO）和斑片影，以胸膜下分布为主；23例（16.31%）GGO合并局灶实变影；27例（19.15%）小片状模糊影；20例（14.18%）大片状实变影；48例（34.04%）支气管血管束增粗和血管穿行征；5例（3.55%）有空气支气管征象；7例（4.96%）小结节影；5例（3.55%）纤维化、网格影或条索影；7例（4.96%）双侧胸腔积液，4例（2.84%）纵隔或双侧肺门淋巴结肿大。结论:COVID-19的临床特征及HRCT影像表现多样，在COVID-19特定的流行病学背景下，应及时开展胸部HRCT扫描，对疾病做出早期预警。“,”Objective:To summarize the clinical and high resolution CT(HRCT) characteristics of 141 patients with COVID-19.Methods:From January 20 to 28, 2020, 141 COVID-19 patients, 77 males and 64 females, with a median age of 49 (9, 87), were enrolled in the study. The clinical features, laboratory test results and HRCT findings of all patients were analyzed retrospectively.Results:In all of the patients, the decreasing leukocyte countin 38 (26.95%) and lymphocyte ratio in 71 (50.35%), a fever over 37.5 ℃ in 139 (98.58%), coughing in 106 (75.18%), headache in 11 (7.80%), expectoration in 41 (29.08%), chest distress in 93 (65.96%), and diarrhea in 4 (2.84%) were found. The HRCT of all patients were abnormal, including ground glass opacity (GGO) with patchy opacity in 52 (36.88%) mainly distributed along subpleural area, GGO with focal consolidation in 23 (16.31%),small patchy opacity in 27 (19.15%),large patchy consolidation in 20 (14.18%),thickened bronchovascular bundleing and blood vessel crossing the lesion in 48 (34.04%), air bronchus sign in 5 (3.55%), small nodule in 7 (4.96%),fibrous stripes and reticular opacities in 5 (3.55%), bilateral pleural effusion in 7 (4.96%), and mediastinal or bilateral hilar lymphadenopathy in 4 (2.84%).Conclusions:The clinical and HRCT manifestations of COVID-19 are various. Under the specific epidemiological background of COVID-19, chest HRCT scan should be carried out as soon as possible for early warning of this disease.